Probamato
Brand names,
Probamato
Analogs
Probamato
Brand Names Mixture
Probamato
Chemical_Formula
C20H23NS
Probamato
RX_link
No information avaliable
Probamato
fda sheet
Probamato
msds (material safety sheet)
Probamato
Synthesis Reference
No information avaliable
Probamato
Molecular Weight
309.469 g/mol
Probamato
Melting Point
< 25 oC
Probamato
H2O Solubility
Soluble as HCl salt
Probamato
State
Liquid
Probamato
LogP
5.7
Probamato
Dosage Forms
Tablets (oral, 1 mg)
Probamato
Indication
Used for the symptomatic treatment of parkinsonism.
Probamato
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Probamato
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Probamato
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Probamato
Patient Information
Probamato
Organisms Affected
Humans and other mammals