Despasmol
Brand names,
Despasmol
Analogs
Despasmol
Brand Names Mixture
Despasmol
Chemical_Formula
C20H23NS
Despasmol
RX_link
No information avaliable
Despasmol
fda sheet
Despasmol
msds (material safety sheet)
Despasmol
Synthesis Reference
No information avaliable
Despasmol
Molecular Weight
309.469 g/mol
Despasmol
Melting Point
< 25 oC
Despasmol
H2O Solubility
Soluble as HCl salt
Despasmol
State
Liquid
Despasmol
LogP
5.7
Despasmol
Dosage Forms
Tablets (oral, 1 mg)
Despasmol
Indication
Used for the symptomatic treatment of parkinsonism.
Despasmol
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Despasmol
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Despasmol
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Despasmol
Patient Information
Despasmol
Organisms Affected
Humans and other mammals