Tamate
Brand names,
Tamate
Analogs
Tamate
Brand Names Mixture
Tamate
Chemical_Formula
C20H23NS
Tamate
RX_link
No information avaliable
Tamate
fda sheet
Tamate
msds (material safety sheet)
Tamate
Synthesis Reference
No information avaliable
Tamate
Molecular Weight
309.469 g/mol
Tamate
Melting Point
< 25 oC
Tamate
H2O Solubility
Soluble as HCl salt
Tamate
State
Liquid
Tamate
LogP
5.7
Tamate
Dosage Forms
Tablets (oral, 1 mg)
Tamate
Indication
Used for the symptomatic treatment of parkinsonism.
Tamate
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Tamate
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Tamate
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Tamate
Patient Information
Tamate
Organisms Affected
Humans and other mammals