Calmadin
Brand names,
Calmadin
Analogs
Calmadin
Brand Names Mixture
Calmadin
Chemical_Formula
C20H23NS
Calmadin
RX_link
No information avaliable
Calmadin
fda sheet
Calmadin
msds (material safety sheet)
Calmadin
Synthesis Reference
No information avaliable
Calmadin
Molecular Weight
309.469 g/mol
Calmadin
Melting Point
< 25 oC
Calmadin
H2O Solubility
Soluble as HCl salt
Calmadin
State
Liquid
Calmadin
LogP
5.7
Calmadin
Dosage Forms
Tablets (oral, 1 mg)
Calmadin
Indication
Used for the symptomatic treatment of parkinsonism.
Calmadin
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Calmadin
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Calmadin
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Calmadin
Patient Information
Calmadin
Organisms Affected
Humans and other mammals