Amepromat
Brand names,
Amepromat
Analogs
Amepromat
Brand Names Mixture
Amepromat
Chemical_Formula
C20H23NS
Amepromat
RX_link
No information avaliable
Amepromat
fda sheet
Amepromat
msds (material safety sheet)
Amepromat
Synthesis Reference
No information avaliable
Amepromat
Molecular Weight
309.469 g/mol
Amepromat
Melting Point
< 25 oC
Amepromat
H2O Solubility
Soluble as HCl salt
Amepromat
State
Liquid
Amepromat
LogP
5.7
Amepromat
Dosage Forms
Tablets (oral, 1 mg)
Amepromat
Indication
Used for the symptomatic treatment of parkinsonism.
Amepromat
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Amepromat
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Amepromat
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Amepromat
Patient Information
Amepromat
Organisms Affected
Humans and other mammals