Pensive
Brand names,
Pensive
Analogs
Pensive
Brand Names Mixture
Pensive
Chemical_Formula
C20H23NS
Pensive
RX_link
No information avaliable
Pensive
fda sheet
Pensive
msds (material safety sheet)
Pensive
Synthesis Reference
No information avaliable
Pensive
Molecular Weight
309.469 g/mol
Pensive
Melting Point
< 25 oC
Pensive
H2O Solubility
Soluble as HCl salt
Pensive
State
Liquid
Pensive
LogP
5.7
Pensive
Dosage Forms
Tablets (oral, 1 mg)
Pensive
Indication
Used for the symptomatic treatment of parkinsonism.
Pensive
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Pensive
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Pensive
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Pensive
Patient Information
Pensive
Organisms Affected
Humans and other mammals