Estasil
Brand names,
Estasil
Analogs
Estasil
Brand Names Mixture
Estasil
Chemical_Formula
C20H23NS
Estasil
RX_link
No information avaliable
Estasil
fda sheet
Estasil
msds (material safety sheet)
Estasil
Synthesis Reference
No information avaliable
Estasil
Molecular Weight
309.469 g/mol
Estasil
Melting Point
< 25 oC
Estasil
H2O Solubility
Soluble as HCl salt
Estasil
State
Liquid
Estasil
LogP
5.7
Estasil
Dosage Forms
Tablets (oral, 1 mg)
Estasil
Indication
Used for the symptomatic treatment of parkinsonism.
Estasil
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Estasil
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Estasil
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Estasil
Patient Information
Estasil
Organisms Affected
Humans and other mammals