Tranlisant
Brand names,
Tranlisant
Analogs
Tranlisant
Brand Names Mixture
Tranlisant
Chemical_Formula
C20H23NS
Tranlisant
RX_link
No information avaliable
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fda sheet
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msds (material safety sheet)
Tranlisant
Synthesis Reference
No information avaliable
Tranlisant
Molecular Weight
309.469 g/mol
Tranlisant
Melting Point
< 25 oC
Tranlisant
H2O Solubility
Soluble as HCl salt
Tranlisant
State
Liquid
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LogP
5.7
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Dosage Forms
Tablets (oral, 1 mg)
Tranlisant
Indication
Used for the symptomatic treatment of parkinsonism.
Tranlisant
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Tranlisant
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Tranlisant
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Tranlisant
Patient Information
Tranlisant
Organisms Affected
Humans and other mammals