Meproleaf
Brand names,
Meproleaf
Analogs
Meproleaf
Brand Names Mixture
Meproleaf
Chemical_Formula
C20H23NS
Meproleaf
RX_link
No information avaliable
Meproleaf
fda sheet
Meproleaf
msds (material safety sheet)
Meproleaf
Synthesis Reference
No information avaliable
Meproleaf
Molecular Weight
309.469 g/mol
Meproleaf
Melting Point
< 25 oC
Meproleaf
H2O Solubility
Soluble as HCl salt
Meproleaf
State
Liquid
Meproleaf
LogP
5.7
Meproleaf
Dosage Forms
Tablets (oral, 1 mg)
Meproleaf
Indication
Used for the symptomatic treatment of parkinsonism.
Meproleaf
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Meproleaf
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Meproleaf
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Meproleaf
Patient Information
Meproleaf
Organisms Affected
Humans and other mammals