Nephentine

Nephentine Brand names, Nephentine Analogs

Nephentine Brand Names Mixture

No information avaliable

Nephentine Chemical_Formula

C₂₀H₂₃NS

Nephentine RX_link

No information avaliable

Nephentine fda sheet

Nephentine msds (material safety sheet)

Nephentine Synthesis Reference

No information avaliable

Nephentine Molecular Weight

309.469 g/mol

Nephentine Melting Point

< 25 ^oC

Nephentine H₂O Solubility

Soluble as HCl salt

Nephentine State

Liquid

Nephentine LogP

5.7

Nephentine Dosage Forms

Tablets (oral, 1 mg)

Nephentine Indication

Used for the symptomatic treatment of parkinsonism.

Nephentine Pharmacology

Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.

Nephentine Absorption

Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.

Nephentine side effects and Toxicity

Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.

Nephentine Patient Information

Nephentine Organisms Affected

Humans and other mammals