Crestanil
Brand names,
Crestanil
Analogs
Crestanil
Brand Names Mixture
Crestanil
Chemical_Formula
C20H23NS
Crestanil
RX_link
No information avaliable
Crestanil
fda sheet
Crestanil
msds (material safety sheet)
Crestanil
Synthesis Reference
No information avaliable
Crestanil
Molecular Weight
309.469 g/mol
Crestanil
Melting Point
< 25 oC
Crestanil
H2O Solubility
Soluble as HCl salt
Crestanil
State
Liquid
Crestanil
LogP
5.7
Crestanil
Dosage Forms
Tablets (oral, 1 mg)
Crestanil
Indication
Used for the symptomatic treatment of parkinsonism.
Crestanil
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Crestanil
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Crestanil
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Crestanil
Patient Information
Crestanil
Organisms Affected
Humans and other mammals