Procalmadiol
Brand names,
Procalmadiol
Analogs
Procalmadiol
Brand Names Mixture
Procalmadiol
Chemical_Formula
C20H23NS
Procalmadiol
RX_link
No information avaliable
Procalmadiol
fda sheet
Procalmadiol
msds (material safety sheet)
Procalmadiol
Synthesis Reference
No information avaliable
Procalmadiol
Molecular Weight
309.469 g/mol
Procalmadiol
Melting Point
< 25 oC
Procalmadiol
H2O Solubility
Soluble as HCl salt
Procalmadiol
State
Liquid
Procalmadiol
LogP
5.7
Procalmadiol
Dosage Forms
Tablets (oral, 1 mg)
Procalmadiol
Indication
Used for the symptomatic treatment of parkinsonism.
Procalmadiol
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Procalmadiol
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Procalmadiol
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Procalmadiol
Patient Information
Procalmadiol
Organisms Affected
Humans and other mammals