Pankalma
Brand names,
Pankalma
Analogs
Pankalma
Brand Names Mixture
Pankalma
Chemical_Formula
C20H23NS
Pankalma
RX_link
No information avaliable
Pankalma
fda sheet
Pankalma
msds (material safety sheet)
Pankalma
Synthesis Reference
No information avaliable
Pankalma
Molecular Weight
309.469 g/mol
Pankalma
Melting Point
< 25 oC
Pankalma
H2O Solubility
Soluble as HCl salt
Pankalma
State
Liquid
Pankalma
LogP
5.7
Pankalma
Dosage Forms
Tablets (oral, 1 mg)
Pankalma
Indication
Used for the symptomatic treatment of parkinsonism.
Pankalma
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Pankalma
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Pankalma
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Pankalma
Patient Information
Pankalma
Organisms Affected
Humans and other mammals