Margonil
Brand names,
Margonil
Analogs
Margonil
Brand Names Mixture
Margonil
Chemical_Formula
C20H23NS
Margonil
RX_link
No information avaliable
Margonil
fda sheet
Margonil
msds (material safety sheet)
Margonil
Synthesis Reference
No information avaliable
Margonil
Molecular Weight
309.469 g/mol
Margonil
Melting Point
< 25 oC
Margonil
H2O Solubility
Soluble as HCl salt
Margonil
State
Liquid
Margonil
LogP
5.7
Margonil
Dosage Forms
Tablets (oral, 1 mg)
Margonil
Indication
Used for the symptomatic treatment of parkinsonism.
Margonil
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Margonil
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Margonil
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Margonil
Patient Information
Margonil
Organisms Affected
Humans and other mammals