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Holbamate Brand names, Holbamate Analogs

Holbamate Brand Names Mixture

  • No information avaliable

Holbamate Chemical_Formula


Holbamate RX_link

No information avaliable

Holbamate fda sheet

Holbamate msds (material safety sheet)

Holbamate Synthesis Reference

No information avaliable

Holbamate Molecular Weight

309.469 g/mol

Holbamate Melting Point

< 25 oC

Holbamate H2O Solubility

Soluble as HCl salt

Holbamate State


Holbamate LogP


Holbamate Dosage Forms

Tablets (oral, 1 mg)

Holbamate Indication

Used for the symptomatic treatment of parkinsonism.

Holbamate Pharmacology

Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.

Holbamate Absorption

Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.

Holbamate side effects and Toxicity

Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.

Holbamate Patient Information

Holbamate Organisms Affected

Humans and other mammals