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Mepron Brand names, Mepron Analogs

Mepron Brand Names Mixture

  • No information avaliable

Mepron Chemical_Formula


Mepron RX_link

Mepron fda sheet

Mepron FDA

Mepron msds (material safety sheet)

Mepron Synthesis Reference

No information avaliable

Mepron Molecular Weight

366.837 g/mol

Mepron Melting Point

No information avaliable

Mepron H2O Solubility

Practically insoluble

Mepron State


Mepron LogP


Mepron Dosage Forms

Suspension; Tablet

Mepron Indication

For the treatment or prevention of Pneumocystis carinii pneumonia in patients who are intolerant to trimethoprim-sulfamethoxazole (TMP-SMX). Also indicated for the acute oral treatment of mild to moderate PCP in patients who are intolerant to TMP-SMX.

Mepron Pharmacology

Atovaquone is a highly lipophilic drug that closely resembles the structure ubiquinone. Its inhibitory effect being comparable to ubiquinone, in sensitive parasites atovaquone can act by selectively affecting mitochondrial electron transport and parallel processes such as ATP and pyrimidine biosynthesis. For illustration, cytochrome bc1 complex (complex III) seems to serve as a highly discriminating molecular target for atovaquone in Plasmodia

Mepron Absorption

The bioavailability of atovaquone is low and variable and is highly dependent on formulation and diet. Bioavailability of the suspension increases two-fold when administered with meals. When administered with food, bioavailability is approximately 47%. Without food, the bioavailability is 23%.

Mepron side effects and Toxicity

The median lethal dose is higher than the maximum oral dose tested in mice and rats (1825 mg/kg per day). Overdoses up to 31,500 mg of atovaquone have been reported. In one such patient who also took an unspecified dose of dapsone, methemoglobinemia occurred. Rash has also been reported after overdose.

Mepron Patient Information

Mepron Organisms Affected

Plasmodium and other