Orlevol
Brand names,
Orlevol
Analogs
Orlevol
Brand Names Mixture
Orlevol
Chemical_Formula
C20H23NS
Orlevol
RX_link
No information avaliable
Orlevol
fda sheet
Orlevol
msds (material safety sheet)
Orlevol
Synthesis Reference
No information avaliable
Orlevol
Molecular Weight
309.469 g/mol
Orlevol
Melting Point
< 25 oC
Orlevol
H2O Solubility
Soluble as HCl salt
Orlevol
State
Liquid
Orlevol
LogP
5.7
Orlevol
Dosage Forms
Tablets (oral, 1 mg)
Orlevol
Indication
Used for the symptomatic treatment of parkinsonism.
Orlevol
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Orlevol
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Orlevol
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Orlevol
Patient Information
Orlevol
Organisms Affected
Humans and other mammals