Restinal
Brand names,
Restinal
Analogs
Restinal
Brand Names Mixture
Restinal
Chemical_Formula
C20H23NS
Restinal
RX_link
No information avaliable
Restinal
fda sheet
Restinal
msds (material safety sheet)
Restinal
Synthesis Reference
No information avaliable
Restinal
Molecular Weight
309.469 g/mol
Restinal
Melting Point
< 25 oC
Restinal
H2O Solubility
Soluble as HCl salt
Restinal
State
Liquid
Restinal
LogP
5.7
Restinal
Dosage Forms
Tablets (oral, 1 mg)
Restinal
Indication
Used for the symptomatic treatment of parkinsonism.
Restinal
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Restinal
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Restinal
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Restinal
Patient Information
Restinal
Organisms Affected
Humans and other mammals