Neo-Tran
Brand names,
Neo-Tran
Analogs
Neo-Tran
Brand Names Mixture
Neo-Tran
Chemical_Formula
C20H23NS
Neo-Tran
RX_link
No information avaliable
Neo-Tran
fda sheet
Neo-Tran
msds (material safety sheet)
Neo-Tran
Synthesis Reference
No information avaliable
Neo-Tran
Molecular Weight
309.469 g/mol
Neo-Tran
Melting Point
< 25 oC
Neo-Tran
H2O Solubility
Soluble as HCl salt
Neo-Tran
State
Liquid
Neo-Tran
LogP
5.7
Neo-Tran
Dosage Forms
Tablets (oral, 1 mg)
Neo-Tran
Indication
Used for the symptomatic treatment of parkinsonism.
Neo-Tran
Pharmacology
Metixene is a tertiary antimuscarinic with actions similar to those of atropine; it also has antihistaminic and direct antispasmodic properties. It is used for the symptomatic treatment of parkinsonism, including the alleviation of the extrapyramidal syndrome induced by other drugs such as phenothiazines, but, like other antimuscarinics, it is of no value against tardive dyskinesias. Metixene has been discontinued.
Neo-Tran
Absorption
Absorbed in the gastrointestinal tract following oral administration, however the extent of absorption is not known.
Neo-Tran
side effects and Toxicity
Signs of overdose include dilated and sluggish pupils, warm, dry skin, facial flushing, decreased secretions of the mouth, pharynx, nose, and bronchi, foul-smelling breath, elevated temperature, tachycardia, cardiac arrhythmias, decreased bowel sounds, urinary retention, delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, loss of memory, paranoia, combativeness, and seizures.
Neo-Tran
Patient Information
Neo-Tran
Organisms Affected
Humans and other mammals