Mephabutazone
Brand names,
Mephabutazone
Analogs
Mephabutazone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Mephabutazone
Chemical_Formula
C19H20N2O2
Mephabutazone
RX_link
No information avaliable
Mephabutazone
fda sheet
Mephabutazone
msds (material safety sheet)
Mephabutazone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Mephabutazone
Molecular Weight
308.374 g/mol
Mephabutazone
Melting Point
105 oC
Mephabutazone
H2O Solubility
47.5 mg/L
Mephabutazone
State
Solid
Mephabutazone
LogP
4.214
Mephabutazone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Mephabutazone
Indication
For the treatment of backache and ankylosing spondylitis
Mephabutazone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Mephabutazone
Absorption
No information avaliable
Mephabutazone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Mephabutazone
Patient Information
No information avaliable
Mephabutazone
Organisms Affected
Humans and other mammals