Bizolin 200
Brand names,
Bizolin 200
Analogs
Bizolin 200
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Bizolin 200
Chemical_Formula
C19H20N2O2
Bizolin 200
RX_link
No information avaliable
Bizolin 200
fda sheet
Bizolin 200
msds (material safety sheet)
Bizolin 200
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Bizolin 200
Molecular Weight
308.374 g/mol
Bizolin 200
Melting Point
105 oC
Bizolin 200
H2O Solubility
47.5 mg/L
Bizolin 200
State
Solid
Bizolin 200
LogP
4.214
Bizolin 200
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Bizolin 200
Indication
For the treatment of backache and ankylosing spondylitis
Bizolin 200
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Bizolin 200
Absorption
No information avaliable
Bizolin 200
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Bizolin 200
Patient Information
No information avaliable
Bizolin 200
Organisms Affected
Humans and other mammals