Butone
Brand names,
Butone
Analogs
Butone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butone
Chemical_Formula
C19H20N2O2
Butone
RX_link
No information avaliable
Butone
fda sheet
Butone
msds (material safety sheet)
Butone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butone
Molecular Weight
308.374 g/mol
Butone
Melting Point
105 oC
Butone
H2O Solubility
47.5 mg/L
Butone
State
Solid
Butone
LogP
4.214
Butone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butone
Indication
For the treatment of backache and ankylosing spondylitis
Butone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butone
Absorption
No information avaliable
Butone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butone
Patient Information
No information avaliable
Butone
Organisms Affected
Humans and other mammals