Ecobutazone
Brand names,
Ecobutazone
Analogs
Ecobutazone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Ecobutazone
Chemical_Formula
C19H20N2O2
Ecobutazone
RX_link
No information avaliable
Ecobutazone
fda sheet
Ecobutazone
msds (material safety sheet)
Ecobutazone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Ecobutazone
Molecular Weight
308.374 g/mol
Ecobutazone
Melting Point
105 oC
Ecobutazone
H2O Solubility
47.5 mg/L
Ecobutazone
State
Solid
Ecobutazone
LogP
4.214
Ecobutazone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Ecobutazone
Indication
For the treatment of backache and ankylosing spondylitis
Ecobutazone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Ecobutazone
Absorption
No information avaliable
Ecobutazone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Ecobutazone
Patient Information
No information avaliable
Ecobutazone
Organisms Affected
Humans and other mammals