Ambene
Brand names,
Ambene
Analogs
Ambene
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Ambene
Chemical_Formula
C19H20N2O2
Ambene
RX_link
No information avaliable
Ambene
fda sheet
Ambene
msds (material safety sheet)
Ambene
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Ambene
Molecular Weight
308.374 g/mol
Ambene
Melting Point
105 oC
Ambene
H2O Solubility
47.5 mg/L
Ambene
State
Solid
Ambene
LogP
4.214
Ambene
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Ambene
Indication
For the treatment of backache and ankylosing spondylitis
Ambene
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Ambene
Absorption
No information avaliable
Ambene
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Ambene
Patient Information
No information avaliable
Ambene
Organisms Affected
Humans and other mammals