PharmacyCodes



B.T.Z. en es it fr

B.T.Z. Brand names, B.T.Z. Analogs

B.T.Z. Brand Names Mixture

  • Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)

B.T.Z. Chemical_Formula

C19H20N2O2

B.T.Z. RX_link

No information avaliable

B.T.Z. fda sheet

B.T.Z. msds (material safety sheet)

B.T.Z. MSDS

B.T.Z. Synthesis Reference

Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)

B.T.Z. Molecular Weight

308.374 g/mol

B.T.Z. Melting Point

105 oC

B.T.Z. H2O Solubility

47.5 mg/L

B.T.Z. State

Solid

B.T.Z. LogP

4.214

B.T.Z. Dosage Forms

Bolus; Liquid; Paste; Powder; Solution; Tablet

B.T.Z. Indication

For the treatment of backache and ankylosing spondylitis

B.T.Z. Pharmacology

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

B.T.Z. Absorption

No information avaliable

B.T.Z. side effects and Toxicity

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

B.T.Z. Patient Information

No information avaliable

B.T.Z. Organisms Affected

Humans and other mammals