Artropan
Brand names,
Artropan
Analogs
Artropan
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Artropan
Chemical_Formula
C19H20N2O2
Artropan
RX_link
No information avaliable
Artropan
fda sheet
Artropan
msds (material safety sheet)
Artropan
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Artropan
Molecular Weight
308.374 g/mol
Artropan
Melting Point
105 oC
Artropan
H2O Solubility
47.5 mg/L
Artropan
State
Solid
Artropan
LogP
4.214
Artropan
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Artropan
Indication
For the treatment of backache and ankylosing spondylitis
Artropan
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Artropan
Absorption
No information avaliable
Artropan
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Artropan
Patient Information
No information avaliable
Artropan
Organisms Affected
Humans and other mammals