Buvetzone
Brand names,
Buvetzone
Analogs
Buvetzone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Buvetzone
Chemical_Formula
C19H20N2O2
Buvetzone
RX_link
No information avaliable
Buvetzone
fda sheet
Buvetzone
msds (material safety sheet)
Buvetzone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Buvetzone
Molecular Weight
308.374 g/mol
Buvetzone
Melting Point
105 oC
Buvetzone
H2O Solubility
47.5 mg/L
Buvetzone
State
Solid
Buvetzone
LogP
4.214
Buvetzone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Buvetzone
Indication
For the treatment of backache and ankylosing spondylitis
Buvetzone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Buvetzone
Absorption
No information avaliable
Buvetzone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Buvetzone
Patient Information
No information avaliable
Buvetzone
Organisms Affected
Humans and other mammals