Neo-Zoline
Brand names,
Neo-Zoline
Analogs
Neo-Zoline
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Neo-Zoline
Chemical_Formula
C19H20N2O2
Neo-Zoline
RX_link
No information avaliable
Neo-Zoline
fda sheet
Neo-Zoline
msds (material safety sheet)
Neo-Zoline
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Neo-Zoline
Molecular Weight
308.374 g/mol
Neo-Zoline
Melting Point
105 oC
Neo-Zoline
H2O Solubility
47.5 mg/L
Neo-Zoline
State
Solid
Neo-Zoline
LogP
4.214
Neo-Zoline
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Neo-Zoline
Indication
For the treatment of backache and ankylosing spondylitis
Neo-Zoline
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Neo-Zoline
Absorption
No information avaliable
Neo-Zoline
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Neo-Zoline
Patient Information
No information avaliable
Neo-Zoline
Organisms Affected
Humans and other mammals