Fenibutol
Brand names,
Fenibutol
Analogs
Fenibutol
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Fenibutol
Chemical_Formula
C19H20N2O2
Fenibutol
RX_link
No information avaliable
Fenibutol
fda sheet
Fenibutol
msds (material safety sheet)
Fenibutol
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Fenibutol
Molecular Weight
308.374 g/mol
Fenibutol
Melting Point
105 oC
Fenibutol
H2O Solubility
47.5 mg/L
Fenibutol
State
Solid
Fenibutol
LogP
4.214
Fenibutol
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Fenibutol
Indication
For the treatment of backache and ankylosing spondylitis
Fenibutol
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Fenibutol
Absorption
No information avaliable
Fenibutol
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Fenibutol
Patient Information
No information avaliable
Fenibutol
Organisms Affected
Humans and other mammals