Phenylbutaz
Brand names,
Phenylbutaz
Analogs
Phenylbutaz
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Phenylbutaz
Chemical_Formula
C19H20N2O2
Phenylbutaz
RX_link
No information avaliable
Phenylbutaz
fda sheet
Phenylbutaz
msds (material safety sheet)
Phenylbutaz
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Phenylbutaz
Molecular Weight
308.374 g/mol
Phenylbutaz
Melting Point
105 oC
Phenylbutaz
H2O Solubility
47.5 mg/L
Phenylbutaz
State
Solid
Phenylbutaz
LogP
4.214
Phenylbutaz
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Phenylbutaz
Indication
For the treatment of backache and ankylosing spondylitis
Phenylbutaz
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Phenylbutaz
Absorption
No information avaliable
Phenylbutaz
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Phenylbutaz
Patient Information
No information avaliable
Phenylbutaz
Organisms Affected
Humans and other mammals