Azolid
Brand names,
Azolid
Analogs
Azolid
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Azolid
Chemical_Formula
C19H20N2O2
Azolid
RX_link
No information avaliable
Azolid
fda sheet
Azolid
msds (material safety sheet)
Azolid
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Azolid
Molecular Weight
308.374 g/mol
Azolid
Melting Point
105 oC
Azolid
H2O Solubility
47.5 mg/L
Azolid
State
Solid
Azolid
LogP
4.214
Azolid
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Azolid
Indication
For the treatment of backache and ankylosing spondylitis
Azolid
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Azolid
Absorption
No information avaliable
Azolid
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Azolid
Patient Information
No information avaliable
Azolid
Organisms Affected
Humans and other mammals