Schemergin
Brand names,
Schemergin
Analogs
Schemergin
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Schemergin
Chemical_Formula
C19H20N2O2
Schemergin
RX_link
No information avaliable
Schemergin
fda sheet
Schemergin
msds (material safety sheet)
Schemergin
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Schemergin
Molecular Weight
308.374 g/mol
Schemergin
Melting Point
105 oC
Schemergin
H2O Solubility
47.5 mg/L
Schemergin
State
Solid
Schemergin
LogP
4.214
Schemergin
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Schemergin
Indication
For the treatment of backache and ankylosing spondylitis
Schemergin
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Schemergin
Absorption
No information avaliable
Schemergin
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Schemergin
Patient Information
No information avaliable
Schemergin
Organisms Affected
Humans and other mammals