Nadozone
Brand names,
Nadozone
Analogs
Nadozone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Nadozone
Chemical_Formula
C19H20N2O2
Nadozone
RX_link
No information avaliable
Nadozone
fda sheet
Nadozone
msds (material safety sheet)
Nadozone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Nadozone
Molecular Weight
308.374 g/mol
Nadozone
Melting Point
105 oC
Nadozone
H2O Solubility
47.5 mg/L
Nadozone
State
Solid
Nadozone
LogP
4.214
Nadozone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Nadozone
Indication
For the treatment of backache and ankylosing spondylitis
Nadozone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Nadozone
Absorption
No information avaliable
Nadozone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Nadozone
Patient Information
No information avaliable
Nadozone
Organisms Affected
Humans and other mammals