Phenylbutazonum
Brand names,
Phenylbutazonum
Analogs
Phenylbutazonum
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Phenylbutazonum
Chemical_Formula
C19H20N2O2
Phenylbutazonum
RX_link
No information avaliable
Phenylbutazonum
fda sheet
Phenylbutazonum
msds (material safety sheet)
Phenylbutazonum
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Phenylbutazonum
Molecular Weight
308.374 g/mol
Phenylbutazonum
Melting Point
105 oC
Phenylbutazonum
H2O Solubility
47.5 mg/L
Phenylbutazonum
State
Solid
Phenylbutazonum
LogP
4.214
Phenylbutazonum
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Phenylbutazonum
Indication
For the treatment of backache and ankylosing spondylitis
Phenylbutazonum
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Phenylbutazonum
Absorption
No information avaliable
Phenylbutazonum
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Phenylbutazonum
Patient Information
No information avaliable
Phenylbutazonum
Organisms Affected
Humans and other mammals