Diphebuzol
Brand names,
Diphebuzol
Analogs
Diphebuzol
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Diphebuzol
Chemical_Formula
C19H20N2O2
Diphebuzol
RX_link
No information avaliable
Diphebuzol
fda sheet
Diphebuzol
msds (material safety sheet)
Diphebuzol
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Diphebuzol
Molecular Weight
308.374 g/mol
Diphebuzol
Melting Point
105 oC
Diphebuzol
H2O Solubility
47.5 mg/L
Diphebuzol
State
Solid
Diphebuzol
LogP
4.214
Diphebuzol
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Diphebuzol
Indication
For the treatment of backache and ankylosing spondylitis
Diphebuzol
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Diphebuzol
Absorption
No information avaliable
Diphebuzol
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Diphebuzol
Patient Information
No information avaliable
Diphebuzol
Organisms Affected
Humans and other mammals