Fenylbutazon
Brand names,
Fenylbutazon
Analogs
Fenylbutazon
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Fenylbutazon
Chemical_Formula
C19H20N2O2
Fenylbutazon
RX_link
No information avaliable
Fenylbutazon
fda sheet
Fenylbutazon
msds (material safety sheet)
Fenylbutazon
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Fenylbutazon
Molecular Weight
308.374 g/mol
Fenylbutazon
Melting Point
105 oC
Fenylbutazon
H2O Solubility
47.5 mg/L
Fenylbutazon
State
Solid
Fenylbutazon
LogP
4.214
Fenylbutazon
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Fenylbutazon
Indication
For the treatment of backache and ankylosing spondylitis
Fenylbutazon
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Fenylbutazon
Absorption
No information avaliable
Fenylbutazon
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Fenylbutazon
Patient Information
No information avaliable
Fenylbutazon
Organisms Affected
Humans and other mammals