Shigrodin
Brand names,
Shigrodin
Analogs
Shigrodin
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Shigrodin
Chemical_Formula
C19H20N2O2
Shigrodin
RX_link
No information avaliable
Shigrodin
fda sheet
Shigrodin
msds (material safety sheet)
Shigrodin
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Shigrodin
Molecular Weight
308.374 g/mol
Shigrodin
Melting Point
105 oC
Shigrodin
H2O Solubility
47.5 mg/L
Shigrodin
State
Solid
Shigrodin
LogP
4.214
Shigrodin
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Shigrodin
Indication
For the treatment of backache and ankylosing spondylitis
Shigrodin
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Shigrodin
Absorption
No information avaliable
Shigrodin
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Shigrodin
Patient Information
No information avaliable
Shigrodin
Organisms Affected
Humans and other mammals