Febuzina
Brand names,
Febuzina
Analogs
Febuzina
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Febuzina
Chemical_Formula
C19H20N2O2
Febuzina
RX_link
No information avaliable
Febuzina
fda sheet
Febuzina
msds (material safety sheet)
Febuzina
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Febuzina
Molecular Weight
308.374 g/mol
Febuzina
Melting Point
105 oC
Febuzina
H2O Solubility
47.5 mg/L
Febuzina
State
Solid
Febuzina
LogP
4.214
Febuzina
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Febuzina
Indication
For the treatment of backache and ankylosing spondylitis
Febuzina
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Febuzina
Absorption
No information avaliable
Febuzina
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Febuzina
Patient Information
No information avaliable
Febuzina
Organisms Affected
Humans and other mammals