Artrizone
Brand names,
Artrizone
Analogs
Artrizone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Artrizone
Chemical_Formula
C19H20N2O2
Artrizone
RX_link
No information avaliable
Artrizone
fda sheet
Artrizone
msds (material safety sheet)
Artrizone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Artrizone
Molecular Weight
308.374 g/mol
Artrizone
Melting Point
105 oC
Artrizone
H2O Solubility
47.5 mg/L
Artrizone
State
Solid
Artrizone
LogP
4.214
Artrizone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Artrizone
Indication
For the treatment of backache and ankylosing spondylitis
Artrizone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Artrizone
Absorption
No information avaliable
Artrizone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Artrizone
Patient Information
No information avaliable
Artrizone
Organisms Affected
Humans and other mammals