Phenbutazol
Brand names,
Phenbutazol
Analogs
Phenbutazol
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Phenbutazol
Chemical_Formula
C19H20N2O2
Phenbutazol
RX_link
No information avaliable
Phenbutazol
fda sheet
Phenbutazol
msds (material safety sheet)
Phenbutazol
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Phenbutazol
Molecular Weight
308.374 g/mol
Phenbutazol
Melting Point
105 oC
Phenbutazol
H2O Solubility
47.5 mg/L
Phenbutazol
State
Solid
Phenbutazol
LogP
4.214
Phenbutazol
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Phenbutazol
Indication
For the treatment of backache and ankylosing spondylitis
Phenbutazol
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Phenbutazol
Absorption
No information avaliable
Phenbutazol
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Phenbutazol
Patient Information
No information avaliable
Phenbutazol
Organisms Affected
Humans and other mammals