Bunetzone
Brand names,
Bunetzone
Analogs
Bunetzone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Bunetzone
Chemical_Formula
C19H20N2O2
Bunetzone
RX_link
No information avaliable
Bunetzone
fda sheet
Bunetzone
msds (material safety sheet)
Bunetzone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Bunetzone
Molecular Weight
308.374 g/mol
Bunetzone
Melting Point
105 oC
Bunetzone
H2O Solubility
47.5 mg/L
Bunetzone
State
Solid
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LogP
4.214
Bunetzone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Bunetzone
Indication
For the treatment of backache and ankylosing spondylitis
Bunetzone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Bunetzone
Absorption
No information avaliable
Bunetzone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Bunetzone
Patient Information
No information avaliable
Bunetzone
Organisms Affected
Humans and other mammals