Anuspiramin
Brand names,
Anuspiramin
Analogs
Anuspiramin
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Anuspiramin
Chemical_Formula
C19H20N2O2
Anuspiramin
RX_link
No information avaliable
Anuspiramin
fda sheet
Anuspiramin
msds (material safety sheet)
Anuspiramin
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Anuspiramin
Molecular Weight
308.374 g/mol
Anuspiramin
Melting Point
105 oC
Anuspiramin
H2O Solubility
47.5 mg/L
Anuspiramin
State
Solid
Anuspiramin
LogP
4.214
Anuspiramin
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Anuspiramin
Indication
For the treatment of backache and ankylosing spondylitis
Anuspiramin
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Anuspiramin
Absorption
No information avaliable
Anuspiramin
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Anuspiramin
Patient Information
No information avaliable
Anuspiramin
Organisms Affected
Humans and other mammals