Tazone
Brand names,
Tazone
Analogs
Tazone
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Tazone
Chemical_Formula
C19H20N2O2
Tazone
RX_link
No information avaliable
Tazone
fda sheet
Tazone
msds (material safety sheet)
Tazone
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Tazone
Molecular Weight
308.374 g/mol
Tazone
Melting Point
105 oC
Tazone
H2O Solubility
47.5 mg/L
Tazone
State
Solid
Tazone
LogP
4.214
Tazone
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Tazone
Indication
For the treatment of backache and ankylosing spondylitis
Tazone
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Tazone
Absorption
No information avaliable
Tazone
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Tazone
Patient Information
No information avaliable
Tazone
Organisms Affected
Humans and other mammals