Azobutyl
Brand names,
Azobutyl
Analogs
Azobutyl
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Azobutyl
Chemical_Formula
C19H20N2O2
Azobutyl
RX_link
No information avaliable
Azobutyl
fda sheet
Azobutyl
msds (material safety sheet)
Azobutyl
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Azobutyl
Molecular Weight
308.374 g/mol
Azobutyl
Melting Point
105 oC
Azobutyl
H2O Solubility
47.5 mg/L
Azobutyl
State
Solid
Azobutyl
LogP
4.214
Azobutyl
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Azobutyl
Indication
For the treatment of backache and ankylosing spondylitis
Azobutyl
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Azobutyl
Absorption
No information avaliable
Azobutyl
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Azobutyl
Patient Information
No information avaliable
Azobutyl
Organisms Affected
Humans and other mammals