Butadion
Brand names,
Butadion
Analogs
Butadion
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Butadion
Chemical_Formula
C19H20N2O2
Butadion
RX_link
No information avaliable
Butadion
fda sheet
Butadion
msds (material safety sheet)
Butadion
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Butadion
Molecular Weight
308.374 g/mol
Butadion
Melting Point
105 oC
Butadion
H2O Solubility
47.5 mg/L
Butadion
State
Solid
Butadion
LogP
4.214
Butadion
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Butadion
Indication
For the treatment of backache and ankylosing spondylitis
Butadion
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Butadion
Absorption
No information avaliable
Butadion
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Butadion
Patient Information
No information avaliable
Butadion
Organisms Affected
Humans and other mammals