Fenilbutazona
Brand names,
Fenilbutazona
Analogs
Fenilbutazona
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Fenilbutazona
Chemical_Formula
C19H20N2O2
Fenilbutazona
RX_link
No information avaliable
Fenilbutazona
fda sheet
Fenilbutazona
msds (material safety sheet)
Fenilbutazona
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Fenilbutazona
Molecular Weight
308.374 g/mol
Fenilbutazona
Melting Point
105 oC
Fenilbutazona
H2O Solubility
47.5 mg/L
Fenilbutazona
State
Solid
Fenilbutazona
LogP
4.214
Fenilbutazona
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Fenilbutazona
Indication
For the treatment of backache and ankylosing spondylitis
Fenilbutazona
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Fenilbutazona
Absorption
No information avaliable
Fenilbutazona
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Fenilbutazona
Patient Information
No information avaliable
Fenilbutazona
Organisms Affected
Humans and other mammals