Pyrabutol en es it fr

Pyrabutol Brand names, Pyrabutol Analogs

Pyrabutol Brand Names Mixture

  • Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
  • Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)

Pyrabutol Chemical_Formula


Pyrabutol RX_link

No information avaliable

Pyrabutol fda sheet

Pyrabutol msds (material safety sheet)

Pyrabutol MSDS

Pyrabutol Synthesis Reference

Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)

Pyrabutol Molecular Weight

308.374 g/mol

Pyrabutol Melting Point

105 oC

Pyrabutol H2O Solubility

47.5 mg/L

Pyrabutol State


Pyrabutol LogP


Pyrabutol Dosage Forms

Bolus; Liquid; Paste; Powder; Solution; Tablet

Pyrabutol Indication

For the treatment of backache and ankylosing spondylitis

Pyrabutol Pharmacology

Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation

Pyrabutol Absorption

No information avaliable

Pyrabutol side effects and Toxicity

Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)

Pyrabutol Patient Information

No information avaliable

Pyrabutol Organisms Affected

Humans and other mammals