Reumazin
Brand names,
Reumazin
Analogs
Reumazin
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Reumazin
Chemical_Formula
C19H20N2O2
Reumazin
RX_link
No information avaliable
Reumazin
fda sheet
Reumazin
msds (material safety sheet)
Reumazin
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Reumazin
Molecular Weight
308.374 g/mol
Reumazin
Melting Point
105 oC
Reumazin
H2O Solubility
47.5 mg/L
Reumazin
State
Solid
Reumazin
LogP
4.214
Reumazin
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Reumazin
Indication
For the treatment of backache and ankylosing spondylitis
Reumazin
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Reumazin
Absorption
No information avaliable
Reumazin
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Reumazin
Patient Information
No information avaliable
Reumazin
Organisms Affected
Humans and other mammals