Buta Phen
Brand names,
Buta Phen
Analogs
Buta Phen
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Buta Phen
Chemical_Formula
C19H20N2O2
Buta Phen
RX_link
No information avaliable
Buta Phen
fda sheet
Buta Phen
msds (material safety sheet)
Buta Phen
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Buta Phen
Molecular Weight
308.374 g/mol
Buta Phen
Melting Point
105 oC
Buta Phen
H2O Solubility
47.5 mg/L
Buta Phen
State
Solid
Buta Phen
LogP
4.214
Buta Phen
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Buta Phen
Indication
For the treatment of backache and ankylosing spondylitis
Buta Phen
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Buta Phen
Absorption
No information avaliable
Buta Phen
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Buta Phen
Patient Information
No information avaliable
Buta Phen
Organisms Affected
Humans and other mammals