Reumasyl
Brand names,
Reumasyl
Analogs
Reumasyl
Brand Names Mixture
- Alka Phenyl Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Alka Phenylbutazone Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
- Phenylone Plus Tab (Aluminum Hydroxide + Magnesium Trisilicate + Phenylbutazone)
Reumasyl
Chemical_Formula
C19H20N2O2
Reumasyl
RX_link
No information avaliable
Reumasyl
fda sheet
Reumasyl
msds (material safety sheet)
Reumasyl
Synthesis Reference
Ullmann's Encyklopaedie der Technischen Chemie 13, 298 (1962)
Reumasyl
Molecular Weight
308.374 g/mol
Reumasyl
Melting Point
105 oC
Reumasyl
H2O Solubility
47.5 mg/L
Reumasyl
State
Solid
Reumasyl
LogP
4.214
Reumasyl
Dosage Forms
Bolus; Liquid; Paste; Powder; Solution; Tablet
Reumasyl
Indication
For the treatment of backache and ankylosing spondylitis
Reumasyl
Pharmacology
Phenylbutazone is a synthetic, pyrazolone derivative. It is a nonhormonal anti-inflammatory, antipyretic compound useful in the management of inflammatory conditions. The apparent analgesic effect is probably related mainly to the compound's anti-inflammatory properties and arise from its ability to reduce production of prostaglandin H and prostacyclin. Prostaglandins act on a variety of cells such as vascular smooth muscle cells causing constriction or dilation, on platelets causing aggregation or disaggregation and on spinal neurons causing pain. Prostacylcin causes vascular constriction platelet disaggregation
Reumasyl
Absorption
No information avaliable
Reumasyl
side effects and Toxicity
Oral, LD50 = 238 mg/kg (mouse); Oral, LD50 = 781 mg/kg (rabbit); Oral, LD50 = 245 mg/kg (rat); Oral, LD50 = 375 mg/kg (rat)
Reumasyl
Patient Information
No information avaliable
Reumasyl
Organisms Affected
Humans and other mammals